When selecting an RF Multiplexer, you must prioritize Frequency Range, Insertion Loss, and Isolation. Ensure the device covers your specific operational bands (e.g., sub-6GHz or mmWave for 5G). Insertion loss should be minimized (typically < 1.0 dB) to maintain signal integrity, while high isolation (typically > 30 dB) is critical to prevent cross-talk between channels. Additionally, verify the Power Handling capacity (measured in Watts) to ensure it meets your system's peak transmission requirements.